Mouse study collective and numbers of mice per experiment.

Five study groups were defined, three of them with transgenic APP/PS1 mice, the others with age- and gender-matched controls. Major subgroups were female. Old refers to an age of about 23 (hemizygous (tg)) and 21 months (homozygous (tgtg)). Young is defined as an age of 9 months. Young homozygous study group (tgtg-young) and both control groups (ctl) were designed to reveal possible gender effects. As an overview and orientation for this study, numbers in each cell state how many animals per subgroup were analyzed in the corresponding experiment. Mean ages, weights and injected doses are shown for each subgroup including standard deviation. The pairwise correlations of these modalities are shown in Figure 7 and Figure S10.(tg: hemizygous APP/PS1, tgtg: homozygous APP/PS1, ctl: C57BL6/J control animals).