Data set - Utility of SOFA Score, Management and Outcomes of Severe Sepsis in Southeast Asia: A Multinational Multicentre Prospective Observational Study

This is an observational study to evaluate the utility of the SOFA score, compliance with Surviving Sepsis Campaign (SSC) 2012 recommendations and factors associated with mortality in adult patients presenting with sepsis (SOFA >=2). The study took place in Thailand, Vietnam, and Indonesia, the partner countries of SEAICRN (Southeast Asia Infectious Disease Clinical Research Network). The registry number of the study was NCT02157259.

The fields contained in the database are as follows:
1. id: Unique identifier for each patient
2. country: The code of the country where each study hospital locates; 2 defines Thailand, 3 defines Vietnam and 4 defines Indonesia
3. site: The code of each study hospital
4. gender: The gender of patients
5. age_group_1: The age group of patients Children and Adults
6. age_group_2: The age group of patients; 1 mo - <1 year, ≥1 - <5 years, ≥5 - <18 years, ≥18 - <40 years, ≥40 - <60 years and ≥60 years old
7. severe_sepsis: severe sepsis defined by Surviving Sepsis Campaign 2012 for adult patients, and by International paediatric sepsis consensus conference 2005 for paediatric patients
8. severe_sofa: sepsis defined by having SOFA score more than or equal to 2 according to the 2014 task force for adult patients; missing value for paediatric patients
9. mortality28: 28-day mortality outcome. Mortality outcome was not available in 19 children and 5 adults who withdrew from the study prior to 28-day follow-up, and in another 13 children and 6 adults who could not be contacted for 28-day outcome.
10. group1_ari: 1 defines patients who had clinical presentations of acute respiratory infection
11. group2_dia: 1 defines patients who had clinical presentations of acute diarrhoea
12. group3_cns: 1 defines patients who had clinical presentations of acute CNS infection
13. group4_si: 1 defines patients who had clinical presentations of acute systematic infection

The following variables represent patients who had pathogens or diseases identified based on a set of diagnostic tests used as described in the main manuscript.
14. any_pathogen: 1 defines patients who had at least one pathogen defined and 0 defines patients who had no pathogen defined
15. bact_01_typhi: 1 defines patients who had Salmonella typhi
16. bact_02_nontyphi: 1 defines patients who had non-typhi Salmonella
17. bact_11_ecoli: 1 defines patients who had Escherichia coli
18. bact_12_k_pneumo: 1 defines patients who had Klebsiella pneumoniae
19. bact_13_k_spp: 1 defines patients who had Klebsiella spp
20. bact_14_enterobacter: 1 defines patients who had Enterobacter spp
21. bact_15_proteus: 1 defines patients who had Proteus spp
22. bact_16_citrobacter: 1 defines patients who had Citrobacter spp
23. bact_17_shigella: 1 defines patients who had Shigella spp
24. bact_21_acineto: 1 defines patients who had Acinetobacter spp
25. bact_22_acrhomobacter: 1 defines patients who had Achromobacter spp
26. bact_23_aeromonas: 1 defines patients who had Aeromonas spp
27. bact_24_haemophillus: 1 defines patients who had Haemophilus spp
28. bact_25_campylobacter: 1 defines patients who had Campylobacter spp
29. bact_26_vibrio: 1 defines patients who had Vibrio spp
30. bact_27_pseudo: 1 defines patients who had Pseudomonas spp
31. bact_28_melioid: 1 defines patients who had Burkholderia pseudomallei
32. bact_31_legionella: 1 defines patients who had Legionella pneumophila
33. bact_32_c_pneumonia: 1 defines patients who had Chlamydophila pneumoniae
34. bact_33_c_psittaci: 1 defines patients who had Chlamydophila psittaci
35. bact_34_bordetella: 1 defines patients who had Bordetella pertussis
36. bact_35_neisseria: 1 defines patients who had Neisseria meningitidis
37. bact_36_other_gn: 1 defines patients who had other Gram-negative bacteria
38. bact_41_aerues: 1 defines patients who had Staphlococcus aureus
39. bact_42_strep_pneumo: 1 defines patients who had Streptococcus pneumoniae
40. bact_43_strep_suis: 1 defines patients who had Streptococcus suis
41. bact_44_strep_spp: 1 defines patients who had Streptococcus spp
42. bact_45_clostridium: 1 defines patients who had Clostridium difficile
43. bact_46_other_gp: 1 defines patients who had other Gram-positive bacteria
44. bact_51_lepto: 1 defines patients who had leptospirosis
45. bact_52_scrub: 1 defines patients who had scrub typhus
46. bact_53_murine: 1 defines patients who had murine typhus
47. bact_54_sfg: 1 defines patients who had spotted fever group
48. bact_55_mycoplasma: 1 defines patients who had Mycoplasma pneumoniae
49. bact_56_tb: 1 defines patients who had Mycobacterium tuberculosis
50. virus_01_dengue: 1 defines patients who had Dengue virus
51. virus_02_hanta: 1 defines patients who had Hantavirus
52. virus_11_influenza: 1 defines patients who had Influenza virus
53. virus_12_adeno: 1 defines patients who had Adenovirus
54. virus_13_entero: 1 defines patients who had Enterovirus
55. virus_14_rsv: 1 defines patients who had Respiratory syncytial virus
56. virus_15_metapneumo: 1 defines patients who had Metapneumovirus
57. virus_16_rhino: 1 defines patients who had Rhinovirus
58. virus_17_para: 1 defines patients who had Parainfluenza virus
59. virus_18_corona: 1 defines patients who had Coronavirus
60. virus_19_boca: 1 defines patients who had Bocavirus
61. virus_20_parecho: 1 defines patients who had Parechovirus
62. virus_21_hsv: 1 defines patients who had Herpes simplex virus
63. virus_22_vzv: 1 defines patients who had Varicella zoster virus
64. virus_23_mumps: 1 defines patients who had Mumps
65. virus_24_measles: 1 defines patients who had Measles
66. virus_25_rubella: 1 defines patients who had Rubella
67. virus_26_je: 1 defines patients who had Japanese encephalitis virus
68. virus_27_ebv: 1 defines patients who had Epstein-Barr virus
69. virus_28_cmv: 1 defines patients who had Cytomegalovirus
70. virus_31_astro: 1 defines patients who had Astrovirus
71. virus_32_noro: 1 defines patients who had Norovirus
72. virus_33_rota: 1 defines patients who had Rotavirus
73. fungus_01_candida: 1 defines patients who had Candida spp
74. fungus_02_cryptococcus: 1 defines patients who had Cryptococcus spp
75. parasite_01_malaria: 1 defines patients who had Malaria
76. parasite_02_cryptosporidium: 1 defines patients who had Cryptosporidium spp
77. parasite_03_strongyloid: 1 defines patients who had Stronglyloides stercoralis
78. parasite_04_e_histo: 1 defines patients who had Entamoeba histolytica

The following variables represent SOFA score and management of severe sepsis.
79. sofa_resp: SOFA respiration score
80. sofa_plt: SOFA coagulation score
81. sofa_liver: SOFA liver score
82. sofa_cvs: SOFA cardiovascular score
83. sofa_cns: SOFA central nervous system score
84. sofa_renal: SOFA renal score
85. sofa_total: total SOFA score
86. ssc_bundle_lactate_measurement: Surviving sepsis campaign care bundle: measured lactate level. 1 defines yes.
87. ssc_bundle_blood_culture_obtain: Surviving sepsis campaign care bundle: obtained blood culture. 1 defines yes.
88. ssc_bundle_parenteral_antibiotic: Surviving sepsis campaign care bundle: administered parenteral antibiotics. 1 defines yes.
89. ssc_bundle_fluid_1500: Surviving sepsis campaign care bundle: administered at least 1,500 ml fluid. 1 defines yes.
90. ssc_bundle_adrenergic: Surviving sepsis campaign care bundle: administered adrenergic agent. 1 defines yes.
91. ssc_bundle_cvp_measurement: Surviving sepsis campaign care bundle: measured central venous pressure. 1 defines yes.
92. ssc_bundle_cvo_measurement: Surviving sepsis campaign care bundle: measured central venous oxygen saturation. 1 defines yes.
93. ssc_bundle_lactate_re: Surviving sepsis campaign care bundle: re-measured lactate level. 1 defines yes.
94. severe_hypotension: Sepsis-induced hypotension from the pre-transfer period up to enrolment. 1 defines yes.
95. severe_inr: Coagulopathy (INR > 1.5) from the pre-transfer period up to enrolment. 1 defines yes, and . defines no INR measurement.
96. severe_hypotension_or_lactate4: Sepsis-induced hypotension or lactate >=4 mmol/L from the pre-transfer period up to enrolment. 1 defines yes.
97. mx_icu: Management: admitted directly to ICU. 1 defines yes.
98. mx_blood_glucose_level: Management: blood glucose level. 0 defines normoglycemia, 1 defines hyperglycaemia, and 2 defines hypoglycaemia.
99. mx_intubation: Management: required mechanical ventilation. 1 defines yes.
100. mx_stree_ulcer_prophylaxis: Management: stress ulcer prophylaxis. 1 defines yes.