Supplementary Material for: Model-Based Attribution of Biologic Effectiveness in Psoriasis

This dataset contains the supplementary material for the manuscript titled 'Model-Based Attribution of Biologic Effectiveness in Psoriasis: Drug vs Context Contributions,' accepted for publication in the Journal of the American Academy of Dermatology (JAAD). The supplementary document provides detailed methodological information and extended analyses supporting the main text, including: 1. Detailed simulation study design, baseline definitions, and parameter values with their respective data sources (Tables S1-S3). 2. Comprehensive explanation of the causal model specification, including Directed Acyclic Graphs (DAG) for PASI90 response (Figure S2). 3. In-depth methodology regarding the Shapley value decomposition framework and the incorporation of contextual modifiers. 4. Extended robustness and sensitivity analyses, including E-value calculations, quantitative bias analysis, and model triangulation approaches. 5. Supplementary figures illustrating the sensitivity of the drug-attributable share to baseline probabilities (Figure S1) and the modeled attribution structures across different biologic classes (Figure S3)."