Alanine- and cysteine-scanning mutagenesis of the V47–V61 rP2X4R segment.
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In this and Table 2, the potency is expressed as the ATP concentration producing 50% of the maximal response (EC50), and the efficacy as the maximum induced current (Imax) in response to 100 µM ATP. The Imax data are expressed as the mean ± SEM from 12–40 measurements per mutant and 96 measurements from the wild type (WT) receptor. n.d., not determined; n.f., nonfunctional;**pmax measurements);*p50 estimation).
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2015-12-02
