Association of Variants Influencing Sphingolipid Concentrations with MI in 3 German Studies.

Association signals with 21 (from 32) variants in 4 chromosomal locations showing genome-wide significant association to circulating sphingolipids, with MI in 3 distinct German patient studies, GerMIFS-I, -II and –III (KORA), differing in their composition by family history of MI [16],[17]. 11 variants across the 5 genes (including all LASS4 variants) were removed due to low imputation quality (Rsq<0 .7) in at least one of the MI cohorts or the control groups (KORAS3, F4 and/or PopGen). Reported p values are age and sex adjusted. A fixed-effects meta-analysis using inverse-variance weighting was used to derive combined odds ratios (Meta OR).