Crystal structure of SAMHD1 dimer bound to deoxyguanosine linked inhibitor
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Crystal structure of SAMHD1 dimer bound to deoxyguanosine linked inhibitor Descriptor: 5'-O-[(R)-(3-{[(1M)-3'-bromo[1,1'-biphenyl]-3-carbonyl]amino}propoxy)(hydroxy)phosphoryl]-2'-deoxyguanosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION Authors: Egleston, M, Dong, L, Howlader, A.H, Bhat, S, Orris, B, Bianchet, M.A, Greenberg, M.M, Stivers, J.T. Deposit date: 2023-02-24 Release date: 2023-06-07 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding. Acs Chem.Biol., 18, 2023
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2023-02-24
