Investigation of Bach2 function by heme-iron homeostasis in red-pulp macrophage.

Macrophages are central in regulating iron homeostasis. Transcription repressor Bach2 regulates by heme. Here we investigated the relationship between heme-regulated Bach2 and macrophage in spleen. We found that gene expression were not many change between WT and Bach2 knock out mice in red-pulp macrophage.Our results suggest that the function of the red-pulp macrophage is not dependent on according to expression of Bach2. Gene expression in red-pulp macrophages cells of WT and Bach2 KO mice was measured. 3 independent mice ware used for each genotype.