Copper-Catalyzed Azidative Multifunctionalization of Alkynes

A facile
and efficient copper-catalyzed azidative multifunctionalization
of alkynes has been developed by using N-fluorobenzenesulfonimide
(NFSI) as both nitrogen source and aryl source and trimethylsilyl
azide (TMSN3) as azido source. This transformation proceeds
under mild conditions, providing a series of α-azido-α-aryl
imine in good yields by a single operation starting from a wide range
of alkynes. The prepared α-azido-α-aryl imines could be
easily converted into 1,5-piperizine-fused 1,2,3-triazoles and azido
enamines.