Rate of transcription elongation and sequence-specific pausing by RNA polymerase I directly influence ribosomal RNA processing

We report altered pause profiles and sensitivity to nucleotide composition in the rpa190-f1205h RNA polymerase I mutant in vivo and in vitro本研究报道了rpa190-f1205h RNA聚合酶I（RNA polymerase I）突变体在体内与体外实验中，其转录暂停谱发生改变，且对核苷酸组成的敏感性出现异常。