Transcriptome analysis of potential candidate genes and molecular pathways in Et-1-deficient mice with depigmentation

To shed lights on the potential candidate genes and molecular pathways in vitiligo pathomechanism and therapeutics, we compared the transcriptomes between depigmented and normal skin in Ets-1 knockout mice that spontaneously exhibit human vitiligo-like depigmentation. We performed gene expression profiling analysis using data obtained from RNA-seq of 1 depigmented and 1 pigmented skins of Ets-1 KO mice, and 1 normal skins of wild-type mice.