microRNA expression in mouse oviduct and Dicer1 tumors. microRNA expression in mouse oviduct and Dicer1 tumors

We developed a genetically engineered conditional compound heterozygous Dicer1 mouse strain that fully recapitulates the bi-allelic mutations of DICER1 in DICER1 syndrome-associated cancers. Embryonic activation of bi-allelic Dicer1 mutations, driven by the anti-Müllerian hormone receptor 2 (Amhr2)-driven Cre strain (Amhr2+/cre), drove cancer development from oviduct. Small RNA sequencing was performed to compare the microRNA expression profiles between tumor and normal oviduct. Overall design: Toal RNA from five control oviduct and 4 Dicer1 tumors were included for sequencing