RNA-seq of human intestinal organoids infected with Salmonella enterica at 2.5h and 8h post infection. RNA-seq of human intestinal organoids infected with Salmonella enterica at 2.5h and 8h post infection

The purpose of this experiment was to identify intestinal epithelial responses to various strains of Salmonella enterica. Human intestinal organoids were infected with three serovars of Salmonella; Typhimurium, Enteritidis and Typhi, as well as type 3 secretion system -1 and -2 mutants in Typhimurium in order to identify host responses that were similar and unique to each serovar, and responses that were dependent on these secretion systems.