Analysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials

The relation of LCT-13910 genotypes and bone mineral density (BMD) has been the subject of modern-day human population studies, giving inconsistent results. In the present study we analyze for the first time a relation of LCT-13910 genotypes and BMD in historical skeletal individuals. Ancient population might be a model for testing this association due to elimination of non-natural factors affecting bone density. Our data from historical medieval individuals suggest possible association of LCT-13910 CC and lower BMD; however, we cannot exclude samples bias due to small population size. Past population could be treated as a model for verification of LCT- BMD association, although to get a better understanding of this relation, future studies should include more ancient individuals from different periods of time.