Human SOD1 co-overexpressed in motor neurons and glial cells and treated with 3 mM BMAA.

Shown are survival rates of 35 day-old male sod1 transgenic flies under 3 mM BMAA treatment (10 flies per vial). Panels A, B and C represent flies expressing mutant human A4V, G85R, wild type SOD1 proteins. The 50% survival rate of A4V, G85R, and hSOD1 when compared with dSOD1 is increased by 8, 30, and 15%, respectively. Differences were considered statistically significant if p

如图所示，为接受3 mM BMAA处理的35日龄雄性sod1转基因果蝇的存活率（每管10只）。图A、B和C分别展示了表达突变型人A4V、G85R、野生型SOD1蛋白的果蝇。与dSOD1相比，A4V、G85R和hSOD1的50%存活率分别提高了8%、30%和15%。若p值低于统计学显著性水平，则认为差异具有统计学意义。