Intramolecular Schmidt Reaction of Acyl Chlorides with Alkyl Azides: Rapid Access to Fused Polycyclic Nitrogen-Containing Heterocycles via a Multistep One-Pot Transformation

The first intramolecular Schmidt reaction of acyl chlorides with alkyl azides has been developed. In this one-pot conversion, an ω-azido hydrocinnamic acid is converted to a tricyclic lactam. The most important feature of the process is the efficiency in bond formation (one bond broken and three new bonds created) and ring construction (two new rings formed).

本研究成功开发了酰氯与烷基叠氮化物之间的首次分子内Schmidt反应。在此一锅转化过程中，ω-叠氮基香豆酸被转化成三环内酰胺。该过程最为显著的特征在于键形成的高效性（断裂一个键并形成三个新键）以及环结构的构建（形成两个新环）。