Figure_3.jpg

MTT viability assay to determine the toxicity of Dynasore in HGFs (A). (B) ZOL-induced viability loss rescue assay where UN indicates untreated (set to 100% viability) and the microM Dynasore concentrations are designated as Dyn 10, Dyn 30, etc. and ZOL is 50 microM in concentration. In panel B the corresponding combination of ZOL and Dynasore vehicles are designated as Combo 10 VEH, Combo 30 VEH, etc. Error bars represent SEM with triple asterisk *** or the plus + indicating p less than or equal to 0.001, double asterisk ** or the hash # indicating p less than or equal to 0.01, and single asterisk * indicating p less than or equal to 0.05. Significant difference comparisons include panel A: indicated doses significantly lower than their respective vehicle control. Panel B: ZOL significantly lower than ZOL VEH and each of the ZOL+ Dyn doses significantly higher than ZOL.