Summary of the self-assembly simulations of the dimers embedded in a DOPC bilayer and in a POPC bilayer.

The total simulation time is the sum of the simulation time of the separate MDs. The number in parentheses represents the number of independent simulations. The total association time is the sum of the time of association of the TM domains observed along the separate MDs. The percentage of the association time of the right-handed structures (R) and the left-handed (L) structures is calculated over the total association time.
The values of the crossing angle and the inter-helix distances (COM distances and contact distances) are an average calculated over the last 10 µs of each of the simulations in the cases of the NRP1 homodimer and the heterodimer. For the PLXA1 homodimer the values are an average calculated over the total time of association in right-handed and left-handed interactions.