Annealing cDNA3' and cDNA5' to Linear ASV DNA Annealing cDNA3' and cDNA5' to Linear ASV DNA

Contributor(s): University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers UCSF Publication: Produced: [1978] Language(s): English Format: Still image Subject(s): Avian Sarcoma Viruses DNA Genre(s): Archival Materials Slides (photographs) Charts (graphic documents) Abstract: In 1976, Harold Varmus and Michael Bishop reported their pathbreaking discovery that a nucleotide sequence--the four letters of the DNA alphabet--of single-stranded, radioactive DNA from the normal cells of various species of birds (cDNA) could "anneal," or associate, with the cancer-causing gene, or oncogene, in Avian sarcoma virus (ASV) to form a double-stranded molecule. Their discovery suggested that normal, non-cancerous cells contain genes--proto-oncogenes, as Varmus and Bishop called them--that might mutate and cause cancer. The ultimate cause of cancer, the two scientists suggested, was to be found within our own genes. This slide provided a schematic of the annealing process. Copyright: This item may be under copyright protection; contact the copyright owner for permission before re-use. Extent: 1 pages NLM Unique ID: 101584926X132 (See in Profiles in Science) Profiles in Science ID: MVBBJQ Permanent Link: http://resource.nlm.nih.gov/101584926X132 Archival Collection: The Harold Varmus Papers (Profiles in Science)