Amino acid segments and sequence types associated with P. falciparum density in the placenta.

IRR, incidence rate ratio (i.e., proportional increase in placental parasite density); CI, confidence interval; IQR, interquartile range; ref., reference category.aReferred to A4 VAR2CSA.b‘x’ indicates positions with 3 or more possible residues, including alignment gaps (see Datasets S1 and S2). Conserved lysine in S3B (K1328 in A4 strain) is underlined.cNegative binomial regression with robust estimation of variance.dMedian of all BepiPred scores for each residue within a sequence type.