Association analysis for risk of MS and single SNPs and haplotypes in <i>VEGF-A</i>.

No genetic association was found between SNPs in the VEGF-A gene and overall risk for MS in 1114 MS (n = 1114) healthy controls (n = 1234). aVEGF-A exon 1 starts at position 43,845,931. All positions according to NCBI SNP database. bAlso denoted −2578C/A. The AA genotype has lower VEGF-A levels [45], [46] and is associated with increased risk of amyotrophic lateral sclerosis in males [17] and increased risk of Alzheimer's disease [18]. cC is the major allele in HapMap. The frequency given in the table is for allele A. dAlso denoted −1154G/A. A-allele and AA-genotype lowers VEGF-A levels [45], [46]. eNo allele frequency data available in HapMap or dbSNP. fM = Major, m = minor allel.