IRAK4 in Complex with Compound 24

IRAK4 in Complex with Compound 24 Descriptor: (6P)-6-[(8R)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-4-({(1s,4S)-4-[1-(difluoromethyl)-1H-pyrazol-4-yl]cyclohexyl}amino)-N-[(2S)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide, Interleukin-1 receptor-associated kinase 4, SULFATE ION Authors: Ferrao, R, Lansdon, E.B. Deposit date: 2025-02-11 Release date: 2025-05-28 Last modified: 2025-06-18 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Discovery of Edecesertib (GS-5718): A Potent, Selective Inhibitor of IRAK4. J.Med.Chem., 68, 2025