Fucntional genetic variants mediate their regulatory effects through altered transcription factor binding. [dirRNA-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117484
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资源简介：
The extensive molecular characterization of the transcriptional regulatory landscape within the LCLs of a 3-generation, 17-member kindred was performed to allow for the identification of functional variants. A variant associated with changes in multiple molecular phenotypes was selected for validation through precise CRISPR/Cas9 editing. Edited clones were subsequently tested for reconstitution of function through CRISPR/dCas9 targeted TF activation. RNA expression within a 3-generation,17-member kindred were assayed using a strand sensitive library construction
创建时间：
2019-08-27
