Fecal microbiome distinguish patients with hyperandrogenic PCOS group from the control PCOS group

The aim of this study was to discover the differences of fecal microbiome between hyperandrogenic PCOS group from the control PCOS group. Methods: We collected 28 fecal samples from PCOS patients with hyperandrogenism (n=14) and PCOS (n=14). Subsequently, fecal microbiomes were characterized and microbial markers of hyperandrogenic PCOS patients were identified. Results: The richness and diversity of gut microbiota in the hyperandrogenic PCOS group were lower than those in the control group. Bifidobacterium, Enterobacteriaceae_unclassified, Streptococcus, Saccharimonadaceae, Enterococcus and Eubacterium_nodatum_group were the characteristic genera of the PCOS patients with hyperandrogenism. Conclusions: This study confirms previous findings and contributes additional evidence of the potential for gut microbial biomarkers to diagnosis hyperandrogenic PCOS subtype.