Compounds of interest identified by screening of the NIH Library in the presence of 3 µM dexamethasone on HMGB1-induced TNFα production.

Compounds of interest are shown with their respective TNFα response and viability values attained in the single compound and combined screens. Drugs that reduced the TNFα response compared to the action of dexamethasone are classified as potentiators. Drugs that decreased the TNFα response by themselves, but showed negligible increase in their activity in combination with dexamethasone are listed as non-potentiators. Compounds that resulted in higher TNFα secretion (>MEAN+2SD) are listed as steroid inhibitors. Compounds that reduced the viability by more than 2 SD (<75% viability) are listed as toxic compounds.