The mutation characteristics and spacing within multiplets in the EGFR gene.

1Spacing (bp) between mutations 1 and 2, followed by the spacing between mutations 2 and 3, etc.2Drug Response: PR-partial response; SD-stable disease; PD-progressive disease.3The deletion is presumed to be the most common 15 bp deletion (c2235_2249).4The identical set of four mutations was reported in three different patients.Bold Face indicates that one mutation in the multiplet resides in a different exon relative to the other clustered mutations in the same exon.