HIV-1 Protease Mutant L76V with Darunavir

HIV-1 Protease Mutant L76V with Darunavir Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION, CHLORIDE ION, ... Authors: Zhang, Y, Weber, I.T. Deposit date: 2010-12-08 Release date: 2011-04-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.46 Å) Cite: The L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic Contacts. Biochemistry, 50, 2011