The Cancer Genome Atlas Head-Neck Squamous Cell Carcinoma Collection

<p>The Cancer Genome Atlas Head-Neck Squamous Cell Carcinoma (TCGA-HNSC) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from <a href="http://cancergenome.nih.gov/">The Cancer Genome Atlas (TCGA)</a>. Clinical, genetic, and pathological data resides in the <a href="https://portal.gdc.cancer.gov/exploration?filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.program.name%22%2C%22value%22%3A%5B%22TCGA%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-HNSC%22%5D%7D%7D%5D%7D">Genomic Data Commons (GDC) Data Portal</a> while the radiological data is stored on The Cancer Imaging Archive (TCIA). </p><p>Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes.  Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type.  For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols.  In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial. </p><h3>CIP TCGA Radiology Initiative</h3><p>Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource.  Learn more about the <a href="/display/Public/TCGA+Head-Neck+Phenotype+Research+Group">TCGA Head-Neck Phenotype Research Group</a>.</p>

肿瘤基因组图谱头颈鳞状细胞癌（TCGA-HNSC）数据集构成了构建一个专注于将癌症表型与基因型相联系的研究社区更大努力的一部分，该社区通过提供与来自《肿瘤基因组图谱》（TCGA）受试者相匹配的临床图像来实现。临床、遗传和病理数据存储于《基因组数据通用平台》（GDC）数据门户，而影像数据则存放在《肿瘤影像存档》（TCIA）中。匹配的TCGA患者标识符使研究人员能够探索TCGA/TCIA数据库，以研究组织基因型、影像表型和患者预后之间的相关性。TCGA所采集的组织样本来自全球多个地点，以实现其累计目标，通常每种癌症类型约为500个样本。因此，图像数据集在扫描方式、制造商和采集协议方面也表现出极高的异质性。在大多数情况下，图像的获取是作为常规护理的一部分，而非作为受控的研究研究或临床试验的一部分。

《CIP TCGA影像学倡议》旨在通过收集和治理提供影像数据的机构参与者所构成的影像来源地点（ISS）群体，借鉴TCGA分析群体的模式，ISS群体被赋予根据上表中的指南为特定癌症类型发表标记论文的机会。这一机会将促进更多参与者加入构建这些多机构数据集，使其成为开放社区资源。了解更多关于《TCGA头颈表型研究小组》的信息。