Replication data for: ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish

This dataset contains raw data from the "DADA2 project". The "DADA2 Project" was aimed at developing and characterizing a zebrafish model of the human adenosine deaminase 2 deficiency (DADA2). In particular, the pathogenetic mechanisms underlying DADA2 were studied in the zebrafish model that was generated, with a particular focus on the contribution of inflammation and adenosine signaling. This project, concluded with the publication of the research article "ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish" (DOI: 10.1038/s42003-024-06286-3), is part of the PhD project "Zebrafish (Danio rerio) as a model system for the functional validation of candidate genes for human diseases", XXXVI cycle, Doctorate School of Experimental Medicine (DMEM), Department of Medical Biotechnology and Translational Medicine (BIOMETRA), University of Milan (https://air.unimi.it/handle/2434/1048908). All data included in the dataset were collected and processed by the authors of the article, under the supervision of Prof. Pistocchi, University of Milan. Most of the data were collected/produced in the laboratories and facilities of the Departments of Medical Biotechnology and Translational Medicine (BIOIMETRA) and Biosciences at the University of Milan. Some data, were collected at San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), at Institute of Cancer and Genomic Sciences - University of Birmingham (Birmingham) and at Department of Development, Institut de la Vision (Paris). The dataset contains raw data which are organized in a set of folders, each one corresponding to a figure presented in the paper associated to this project. Each folder is then organized in subfolders, each one containig raw data as described in the "README" files.