RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression

NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulating lipid homeostasis in the liver and adipose tissues by using tissue-specific HuR knockout mice. However, the underlying mechanism by which hepatocyte-specific HuR regulates hepatic lipid metabolism under metabolic stress remains unclear and is the focus of this study. Comparative gene expression profiling analysis for the livers of wild type mice and hepatocyte-specific HuR knockout mice fed Western Diet and sugar water.