Colorectal cancer (CRC) ranks third in incidence and second in mortality among cancers worldwide. Emerging researches showed that microRNAs (miRNAs) play an important role in CRC progression. Here, we

NIAID Data Ecosystem30

FLANC, a novel primate-specific long non-coding RNA, is involved in colorectal carcinogenesis and holds potential as a novel therapeutic target (shRNA). FLANC, a novel primate-specific long non-coding RNA, is involved in colorectal carcinogenesis and holds potential as a novel therapeutic target (shRNA)

结直肠癌分子机制

非编码RNA靶点

FLANC is significantly up-regulated in two cohorts of CRC samples and high level of FLANC is associated with poor patient survival in two additional independent cohorts. FLANC influences cellular grow

NIAID Data Ecosystem30

Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [HCT116]

炎症调控

结直肠癌分子机制

Chronic inflammation is epidemiologically linked to the pathogenesis of gastrointestinal diseases, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, our understanding of

NIAID Data Ecosystem30

An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [rnaseq_ls180]. An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [rnaseq_ls180]

结直肠癌分子机制

RNA-seq转录组学

Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant prope

NIAID Data Ecosystem30

Proteomics of ACF as they mature and transform into intestinal adenomas

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