Asymmetric NHC-Catalyzed Aza-Diels–Alder Reactions: Highly Enantioselective Route to α‑Amino Acid Derivatives and DFT Calculations
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https://figshare.com/articles/dataset/Asymmetric_NHC_Catalyzed_Aza_Diels_Alder_Reactions_Highly_Enantioselective_Route_to_Amino_Acid_Derivatives_and_DFT_Calculations/2269237
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资源简介：
A facile N-heterocyclic
carbene catalytic enantioselective
aza-Diels–Alder reaction of oxodiazenes with α-chloroaldehydes
as dienophile precursors is reported, with excellent enantioselectivity
(ee > 99%) and excellent yield (up to 93%). DFT study showed that cis-TSa, formed from a top face approach of
oxodiazene to cis-IIa, is the most favorable
transition state and is consistent with the experimental observations.
创建时间：
2014-08-01
