Asymmetric NHC-Catalyzed Aza-Diels–Alder Reactions: Highly Enantioselective Route to α‑Amino Acid Derivatives and DFT Calculations
收藏NIAID Data Ecosystem2026-03-08 收录
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资源简介：
A facile N-heterocyclic carbene catalytic enantioselective aza-Diels–Alder reaction of oxodiazenes with α-chloroaldehydes as dienophile precursors is reported, with excellent enantioselectivity (ee > 99%) and excellent yield (up to 93%). DFT study showed that cis-TSa, formed from a top face approach of oxodiazene to cis-IIa, is the most favorable transition state and is consistent with the experimental observations.
创建时间：
2014-08-01
