CLINICAL - GENEALOGICAL ANALYSIS OF MUCOVISCIDOSIS

1. The genetic relations in families with mucoviscidosis found in the present clinical material do not correspond to the true segregational relations of the fre­quencies of the affected children. 2. One of the reasons which influence the increase of the frequency of affected children in families with mucoviscidosis on condition of incomplete detection is the diagnostic dependence in many cases upon the presence of the affected or dead sibs in a family, 3. The analysis of segregation in families found by the first affected child elimi­nates the diagnostic dependence and makes the sample random. 4. The established fact of diagnostic dependence upon the presence of the second patient in a family may be the natural cause of the deviation of segrega- tional relations in some other hereditary diseases which are characterized by a wide clinical polymorphism.