Post-challenge sickness score in mice vaccinated with indicated vaccine regimens.

Mice were evaluated and scored for individual symptoms. Rough hair (absent = 0, present = 1), activity (normal = 0, reduced = 1, severely reduced = 2), hunched (absent = 0, present = 1), eye swelling (absent = 0, present = 1). The final score was the addition of each individual score. The minimum score was 0 for healthy and 1–5 depending upon the severity. Each score represents the mean values of six animals and the standard deviation.