Quercetin promotes in vitro maturation of oocytes from humans and aged mice

The flavonol compound quercetin is considered to be an anti-aging agent due to its cytoprotective actions as an antioxidant. The RNA sequencing analysis of oocytes after in vitro maturation from aged mice identified many genes altered by quercetin treatment and suggested that such treatment has a pronounced impact on genetic programs associated with mitochondrial dysfunction. Overall design: 15 MII stage oocytes after IVM from three mice were considered one group, and three replicates were assessed per group. Samples included groups collected with or without 10 µM quercetin treatment.