Additional file 3: of Global phosphoproteomic analysis identifies SRMS-regulated secondary signaling intermediates

Table S2. The file is organized into the following spreadsheets: Spreadsheet “Cell. & Biol. processes”: This table shows all the cellular and biological processes identified by IPA analysis ( www.ingenuity.com ) enriched from the upregulated/hyperphosphorylated proteins identified in the SRMS-regulated phosphoproteome. To minimize redundancy, the cellular and biological processes are categorized in specific functional “categories”. Also shown for every cellular and biological process are P-values (Fisher’s exact t-test), activation z-score, predicted activation state (based on a cut-off z-score = +/− 2), protein names and the number of proteins enriched in the corresponding cellular and biological process. Spreadsheet “Upstream regulators”: This table lists all the upstream regulators identified by IPA analysis for the SRMS-dependent upregulated/hyperphosphorylated proteins. Also shown are p-values, activation z-score, predicted activation state (based on a cut-off z-score = +/− 2), protein names and number of proteins for every upstream regulator identified by IPA analyses. Spreadsheet “Signaling pathways”: Shown here are the canonical signaling pathways corresponding to the upregulated/hyperphosphorylated proteins, as identified by IPA analysis. Also shown are the -log p-values, ratio (the ratio estimates the representation of the proteins in each canonical pathway. This is calculated as the ratio of the number of proteins that are enriched in the pathway to the number of proteins in the Ingenuity database reference dataset that make up the pathway) and the protein names corresponding to each canonical pathway. (XLSX 15 kb)