TRIM21 PrySpry domain bound to an enhanced PRLX-93936 analog

TRIM21 PrySpry domain bound to an enhanced PRLX-93936 analog Descriptor: (3P)-3-(4-chloro-2-ethoxyphenyl)-6-fluoro-2-[(piperazin-1-yl)methyl]quinazolin-4(3H)-one, E3 ubiquitin-protein ligase TRIM21 Authors: Hinshaw, S.M, Corsello, S.M, Yuan, L, Lu, J, Martinez, M, Gray, N.S. Deposit date: 2024-11-30 Release date: 2025-08-27 Last modified: 2026-03-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex. Cancer Discov, 15, 2025