This experiment explored the impact of cell volume increase and regulatory volume decrease (RVD) on the transcriptome of mouse macrophages. Bone marrow-derived macrophages (BMDMs) were isolated from
Endogenous molecules generated upon pathogen invasion or tissue damage serve as danger signals that activate host defence, however their precise immunological role remains unclear. Tenascin-C is an ex
Purpose: Identification of cellular pathways regulated by AIF1 in bone marrow derived macrophages, based on gene expression patterns identfied by RNA seq. Methods: Imortalized macrophage cell lines we
BackgroundAtherosclerosis (AS) remains a leading cause of cardiovascular morbidity and mortality, characterized by intricate interactions between immune dysregulation and lipid metabolism abnormalitie
Deletion of Arntl disrupted temporal inflammatory response in macrophage. Mechanistically, the acetylation status of lysine 27 of histone 3 (H3K27ac) was enhanced at the PU.1-containing enhancers in A