Effect of Jietacin derivative on inflammatory cytokine production and phosphorylation of NF-kB in synovial cells

Osteoarthritis (OA) is the most common type of arthritis, and an important cause of disability that degrades quality of life and causes substantia economic loss. Therefore, the development of disease-modifying drugs that confer both structural and symptomatic benefits is needed for OA treatment. We examined the effect of JD on inflammatory cytokine production and phosphorylation of NF-kB in synovial cells.