Expression data in the cerebral cortex of postnatal Dyrk1a+/+ and Dyrk1a+/- mice

DYRK1A is a protein kinase with several roles in brain development. This kinase is involved in two intellectual disability syndromes: Down syndrome and DYRK1A haploinsufficiency syndrome. The Dyrk1a+/- mouse is a model for DYRK1A haploinsufficiency syndrome. We used microarray to evaluate the impact of DYRK1A haploinsufficiency in the development of the cerebral cortex. Total RNA was prepared from the cerebral cortex of 4 Dyrk1a+/+ and 4 Dyrk1a+/- mice at both P0 and P7 for hybridization on Affymetrix Mouse GeneChip 430 2.0 Array.