Pairwise Euler Angle Distances [°] of the bound and free 2C TCR variants.

The structures were superimposed to the α variable domains. All Euler angle distances are given in degrees in respect to averaged geometries of all biological units. Unlike other 2C T7 variants (m6, T7-wt-s, m13) the m67 variant (underlined) affiliates to cluster (C) 6 occupied by the 2C wt TCRs bound to a different ligand. The two clusters are emphasized by bold typesetting.
a) Cluster affiliation.
b) Subtypes.
c) Ligands: U = unbound, KE = H2-K1b+EQYKFYSV, KS = H2-K1b+SIYRYYG, LQ = H2-Ld+QLSPFPFDL. The ligand main type (MHC) is indicated by the first letter in italics.
d) MHC mutation: (F9Y)(V12T)(I23T).
Pairwise Euler Angle Distances [°] of the bound and free 2C TCR variants.