B Cell Receptor CDR3 Repertoires from Brain and Peripheral Tissues Following Experimental Ischemic Stroke in Mice

This dataset provides B cell receptor (BCR) immunoglobulin heavy-chain (IGH), kappa light-chain (IGK), and lambda light-chain (IGL) repertoire sequencing data derived from infarct-core ipsilateral brain tissue and peripheral lymphoid tissues following experimental ischemic stroke in mice. The resource includes both productive and nonproductive BCR clonotypes generated by bulk genomic DNA-based immunosequencing. The dataset encompasses complementary experimental designs, including a single-site age- and sex-stratified cohort and multisite, cross-model replicated studies incorporating transient middle cerebral artery occlusion (tMCAO), distal middle cerebral artery occlusion (dMCAO), and distal middle cerebral artery occlusion with hypoxia (DH) stroke models. Multisite datasets were independently generated across multiple research centers to facilitate assessment of repertoire reproducibility and robustness across experimental stroke paradigms. IGH, IGK, and IGL repertoires are available for the single-site cohort, whereas the multisite dataset contains IGH repertoires exclusively.