Implementing the Design of Experiments (DoE) concept into the development of mucoadhesive tablets containing orange peel extract as a potential concept for the treatment of oral infections

Dissolution.xlsx - data represent the percentage of hesperidin released. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. Tests were performed using the Agilent 708-DS dissolving equipment (Agilent Technologies; Santa Clara, CA, USA). A typical basket method was used, with 50 rpm and stirring at 37 ± 0.5 °C. The concentration was determined using the HPLC method (https://www.mdpi.com/1422-0067/24/9/7963) and converted, relative to the weight (from Tabletability.xlsx), into the percentage of the substance released during the experiment.Swelling_index.xlsx - data represent the swelling index. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. The water sorption aptitude of the artificial saliva solution (pH = 6.8) was used to evaluate the swellability of the tablets. After careful weighing (Wd), each dry tablet was put in a beaker that was filled with solvent. At certain intervals of time, the samples were placed on filter paper to remove excess surface water, and they were then weighed once more (Wf). The swelling ratio was calculated according to the following equation: 𝑆𝑤𝑒𝑙𝑙𝑖𝑛𝑔 𝑖𝑛𝑑𝑒𝑥 (%)=(𝑊𝑓−𝑊𝑑)𝑊𝑑×100Tabletability.xlsx - columns indicate compression force [N], pressure [Mpa], tablet mass [mg], thickness [mm], diameter [mm], hardness [N]; rows the corresponding tablets. Flat-faced, 8 mm in diameter tablets were compressed using a Natoli NP-RD10 (Natoli, Saint Charles, MO, USA) laboratory scale single punch tablet press. Compression force - was read directly from the tablet press, pressure - was read directly from the tablet press, tablet mass - each tablet was weighed separately after the tableting process, thickness - each tablet was measured with a caliper after the tableting process, diameter - each tablet was measured with a caliper after the tableting process, hardness - each tablet was measured with a hardness tester after the tableting process