Copper- and Silver-Catalyzed Diastereo- and Enantioselective Conjugate Addition Reaction of 1‑Pyrroline Esters to Nitroalkenes: Diastereoselectivity Switch by Chiral Metal Complexes
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https://figshare.com/articles/dataset/Copper_and_Silver_Catalyzed_Diastereo_and_Enantioselective_Conjugate_Addition_Reaction_of_1_Pyrroline_Esters_to_Nitroalkenes_Diastereoselectivity_Switch_by_Chiral_Metal_Complexes/2112034
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资源简介：
syn-Diastereoselective
conjugate addition of 1-pyrroline
esters to nitroalkenes in good yields with an excellent enantioselectivity
by using CuOAc/Me-FcPHOX catalyst in the presence of pyridine. In
contrast, AgOAc/tBu-ThioClickFerrophos catalyzed
the anti diastereoselective conjugate addition with
a high enantioselectivity without additional base. Thus, the preparation
of chiral 1-pyrroline derivatives bearing diverse stereochemistry
could be achieved. The diastereoselective reduction of the imine group
in the conjugate adduct could afford the 2,5-cis-proline
ester derivative.
创建时间：
2016-02-12
