Discovery of biomarker proteins in plasma extracellular vesicles from septic patients

Sepsis is a life-threatening condition induced by a dysregulated host response to infection, characterized clinically by systemic inflammation, hemodynamic instability, organ dysfunction, and high mortality. Plasma-derived extracellular vesicles (EVs) have been reported to play a role in mediating pathophysiological responses in sepsis, such as inflammation and coagulation. This study aims to identify biomarkers and elucidate pathways through differentially expressed proteins from plasma-derived EVs in septic patients.