Small RNAs in undifferentiated and differentiating mouse embryonic stem cells. Mus musculus

We report the identification of small RNAs in undifferentiated (d0) and differentiating (d4) mouse embryonic stem (ES) cells using high-throughput sequencing. The goal of this study was to identify small RNAs involved in X-chromosome inactivation (XCI). We have identified a subset of small RNAs that are generated from transposon sequences and map to the X-chromosome, suggesting their involvement in transposon control on the inactivating X-chromosome. Overall design: Examination of 5 small RNA and 4 RNA-seq libraries in 3 ES cell states.