TS and gentian violet reduce tumor volume in a SCID mouse xenograft model of MM.

(A) Hematoxylin and eosin (H&E) stained tumor tissue isolated from the peritoneal cavity of a DMSO control Fox Chase SCID mouse 5 weeks after injection of human HM cells. MM tumors were of biphasic morphology with necrotic areas that stained with eosin (pink staining). Tumors often contained stromal tissue of mouse origin and locally invaded the pancreas, liver and omentum. (B-D) Representative H & E stained tumor tissue from mice treated with 50 mg/kg TS, 2 mg/kg GV, or 5 mg/kg TS plus 2 mg/kg GV, respectively, every other day for 21–25 days. Tumor architecture and morphology was similar between treated and untreated animals (scale bar = 0.5 mm). (E) Tumor volumes from animals treated with 5 mg/kg TS, 50 mg/kg TS, 2mg/kg GV, or 2 mg/kg GV plus 5 mg/kg TS are presented as percent of vehicle control (DMSO) (n = 4–6 animals per group, ** p S5 Fig.