Nur77 induces GSDMC-mediated pyroptosis

Pyroptosis is a type of lytic cell death executed by members of the gasdermin family. It has been demonstrated that induction of pyroptosis can effectively inhibit tumor growth, which implicates a new strategy for clinical tumor therapy, especially for those tumors (such as melanoma) that are insensitive or resistant to the induction of apoptosis.By means of a chemical compound DBIC, designed and identified by our group recently, to induce GSDMC-mediated pyroptosis in melanoma cells. Overall design: To investigate the mechanism of pyroptosis induced by DBIC based on the fact that hemin inhibted DBIC-induced pyroptosis. We then performed gene expression profiling analysis data obtained from RNA-seq of four groups.Comparative gene expression profiling analysis of RNA-seq data for Ctrl, DBIC, Hemin and DBIC+Hemin.