Molecular regulation of melatonin biosynthesis pathway in unipolar and bipolar depression

Melatonin is a neurohormone that maintains the circadian rhythms of the body. Although we know the pathway of melatonin action in the brain, we lack comprehensive cross-sectional studies on the periphery of depressed patients. This study aims to analyze genes uniquely altered after agomelatine treatment in a clinical model and melatonin treatment in a cell culture model.