BIOGRID CURATED DATA FOR SEX-1 (Caenorhabditis elegans)

Protein-Protein, Genetic, and Chemical Interactions for SEX-1 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males.

由 BioGRID (https://thebiogrid.org) 精心整理的 Caenorhabditis elegans 中性染色体1（SEX-1）的蛋白质-蛋白质、遗传和化学相互作用数据集；定义：sex-1 编码一种DNA结合蛋白，该蛋白属于转录调控因子核激素受体超家族成员；在胚胎发育过程中，SEX-1 作为X染色体的信号元件，通过负向调控 xol-1 基因的转录来传递初级性别决定信号，xol-1 基因的表达水平与雌雄同体或雄性发育相关（低 xol-1 水平导致雌雄同体发育，高 xol-1 水平导致雄性发育）；在体内，SEX-1 可以与携带 xol-1 启动子的额外染色体阵列相结合，表明 SEX-1 对 xol-1 转录的影响可能是直接的；从卵母细胞发生到胚胎中期的核中，可见 SEX-1 表达水平最高，尤其是在早期原肠胚阶段（28-100细胞期）；SEX-1 的表达模式在雌雄同体和雄性中似乎相似。